What is Isotretinoin (Accutane)?

Isotretinoin is a powerful retinoid medication primarily used to treat severe or cystic acne that has not responded to other treatments. It works by reducing the size and activity of sebaceous glands, which decreases oil production and prevents acne formation.

Isotretinoin is also prescribed for certain skin conditions, such as rosacea or keratosis pilaris, under the supervision of a dermatologist. It is available under various brand names and is often considered a last-resort treatment due to its potential side effects.

• Generic name: isotretinoin
• Brand names: Accutane, Claravis, Absorica, Myorisan
• Drug classes: Retinoids, dermatological agents

Warnings

• Isotretinoin is strictly contraindicated during pregnancy due to the high risk of severe birth defects.
• Avoid isotretinoin if you have a history of severe depression or suicidal thoughts, as it may exacerbate mental health conditions.
• Blood lipid levels may increase significantly during treatment; regular monitoring is essential.
• Avoid excessive sun exposure and use sunscreen, as isotretinoin can increase sensitivity to sunlight.

Before Using This Product

• Do not use isotretinoin if you are allergic to it or other retinoids.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
• Disclose any history of mental health disorders, liver disease, or high cholesterol.
• Ensure you are enrolled in the iPLEDGE program if prescribed isotretinoin, as it requires strict adherence to safety protocols to prevent pregnancy.

How Should I Take Isotretinoin?

• Dosage: Typically, isotretinoin is prescribed at 0.5-1 mg per kilogram of body weight per day, divided into two doses.
• With Food: Always take isotretinoin with a full meal to enhance absorption.
• Duration: A typical course lasts 15-20 weeks but may vary based on response and side effects.

What Happens If I Miss a Dose?

• Take the missed dose as soon as you remember, unless it is close to the next dose.
• If it is almost time for your next dose, skip the missed dose and resume your normal schedule.
• Do not double doses to make up for a missed dose.

What Happens If I Overdose?

• Symptoms of overdose may include severe headache, dizziness, nausea, vomiting, and peeling skin.
• Seek emergency medical attention or contact a poison control center immediately if overdose symptoms occur.

What to Avoid

• Avoid vitamin A supplements, as they can increase the risk of side effects.
• Avoid waxing or laser treatments during and for 6 months after isotretinoin treatment to prevent scarring.
• Avoid donating blood while taking isotretinoin and for at least one month after discontinuing the medication.

Isotretinoin Side Effects

Common side effects may include:

• Dry skin, lips, and eyes
• Chapped lips
• Temporary hair thinning
• Nosebleeds
• Joint or muscle pain

Seek immediate medical attention if you experience severe side effects, such as:

• Severe mood changes or thoughts of self-harm
• Vision problems or loss
• Severe stomach pain, diarrhea, or rectal bleeding
• Yellowing of the skin or eyes (jaundice)